If taken as an oral supplement, most DHEA is quickly eliminated by the “first-pass effect” of the liver. As a consequence, oral DHEA supplements are minimally effective in yielding any noticeable benefits for the user.
What does increase in the bloodstream from oral DHEA supplements is DHEA-S (DHEA sulfate). It was believed for many years that the body could convert DHEA-S into free DHEA as needed. DHEA-S has a fairly stable level so DHEA-S is what most laboratories do to test “DHEA level” when such a test is ordered by a physician. This is why so many of the studies done in the past showed minimal benefits to DHEA supplement use. Most of these inconclusive studies were done with oral DHEA supplements, and testing of levels of DHEA-S rather than free DHEA.
However, a very important medical research study done by Dr. Fabian Hammer, Dr. Sandra Subtil, Dr. Philipp Lux, Dr. Christiane Maser-Gluth, et al was published in The Journal of Clinical Endocrinology and Metabolism March 8, 2005 entitled “No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and in Vitro Studies” The title of the article describes well what was shown. Basically, DHEA-S cannot be converted into DHEA. DHEA can be converted into DHEA-S, but not the other way around. That is why oral DHEA supplements do not have much of a noticeable effect.
So, the best way to use DHEA is as a properly made bioidentical cream applied on thin hairless skin. Since DHEA is a basic building block for hormones, it must be provided to the body on the dermis (the skin) where it occurs naturally anyway; and if it is provided on the skin each day over time supplementation begins to provide noticeable benefits. This is because we process a lot of the DHEA in the skin; so it makes sense that the best way to use DHEA would be as an absorbable skin cream that puts the DHEA where we use it naturally- the skin. That is why Twist 25 DHEA supplement cream was developed.
A small squirt of Twist 25 cream rubbed in each day (morning and evening is best) can help stave off many of the unpleasant effects of declining hormones as we age.
Twist 25 DHEA cream – Suggested Use: Apply 1-2 pump presses morning and evening each day. Rub in completely between inner arm and abdomen.
The cream is best absorbed when applied to thin hairless skin. It is very good for the skin because DHEA is also a base for sebum, skin oil. DHEA has also been shown to protect skin cells from both Ultraviolet (UV) and chemical carcinogens.
For people 35 and up, male or female, Twist 25 DHEA cream is the right way to help you continue to look your best and feel your best. Medical research shows that higher levels of DHEA are associated good health while lower levels of DHEA are associated with numerous diseases. With strong DHEA levels many measures for quality of life can be improved –
- Energy Levels
- Mental Clarity
- Muscle Tone
- Sexual Desire
- Reduced Risk of Heart Disease
- Better Bone Strength
- Reduced Risk of Cancer
- Reduced Abdominal Fat
- Enhanced Immune Response
- Better Sleep
- Better Skin